Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Ethanol → Ethyl 2-hydroxy-5-[[4-[(3-methyl-2-pyridinylamino)sulfonyl]phenyl]ethynyl]benzoate
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Ethanol | HCID 702 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Ethyl 2-hydroxy-5-iodobenzoate | HCID 13013012 | — |
| 반응물 | 4-ethynyl-N-(3-methyl-2-pyridinyl)benzenesulfonamide | HCID 19423420 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 촉매 | HCID 178418476 | HCID 178418476 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Dimethylacetamide | HCID 31374 | — |
| 생성물 | Ethyl 2-hydroxy-5-[[4-[(3-methyl-2-pyridinylamino)sulfonyl]phenyl]ethynyl]benzoate | HCID 19423387 | 77.9% |
반응 단계
Dichlorobis(triphenylphosphine)palladium (0.07 g, 0. 1 mmol) and copper(I)iodide (0.04 g, 0.2 mmol) were added to a solution of ethyl 2-hydroxy-5-iodobenzoate (14.9 g, 50 mmol) and 4-ethynyl-N-(3-methyl-2-pyridinyl)benzenesulfonamide (14.3 g, 50 mmol) in triethylamine (10 g, 0.1 mol) and dimethylacetamide (60 ml) at 65° C. Hot ethanol was added after 1 h and then hot water (100 ml) with stirring. The solid was filtered off after cooling in the refrigerator and recrystalized from formic acid and water to yield 17.0 g (77%) product.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05302718 |
| 출처 데이터셋 | uspto-grants-1994_04 |
| ORD ID | ord-4417adc9651441d9838bf7f5028e0e50 |
| 출처 메모 | uspto-grants-1994_04 |