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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Ethyl 2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetate → 3,4-Dihydro-3-[2-[2-bromo-5-trifluoromethylphenylamino]-2-oxoethyl]-4-oxophthalazine-1-acetic acid ethyl ester

HRID 1464257
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HRID 1464257 반응식
[O:1]=[C:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C:5]([CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14])=[N:4][NH:3]1.CC(C)([O-])C.[K+].[Br:24][C:25]1[CH:35]=[CH:34][C:33]([C:36]([F:39])([F:38])[F:37])=[CH:32][C:26]=1[NH:27][C:28](=[O:31])[CH2:29]Cl>CN(C)C=O>[CH2:16]([O:15][C:13](=[O:14])[CH2:12][C:5]1[C:6]2[C:11](=[CH:10][CH:9]=[CH:8][CH:7]=2)[C:2](=[O:1])[N:3]([CH2:29][C:28]([NH:27][C:26]2[CH:32]=[C:33]([C:36]([F:37])([F:38])[F:39])[CH:34]=[CH:35][C:25]=2[Br:24])=[O:31])[N:4]=1)[CH3:17]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 348622Ethyl 2-(4-oxo-3,4-dihydrophthalazin-1-yl)acetateHCID 157139482'-Bromo-5'-trifluoromethyl-2-chloroacetanilideHCID 23665647Potassium tert-butoxide

생성물 1

HCID 99580483,4-Dihydro-3-[2-[2-bromo-5-trifluoromethylphenylamino]-2-oxoethyl]-4-oxophthalazine-1-acetic acid ethyl ester

시약·촉매·용매 1

HCID 6228Dimethylformamide
용매
2회

실험 절차

To a solution of ethyl 4-oxo-3H-phthalazin-1-ylacetate (3.36 g) and potassium t-butoxide (1.62 g) in dimethylformamide (15 ml) was slowly added a solution of 2'-bromo-5'-trifluoromethyl-2-chloroacetanilide (4.55 g) in dimethylformamide (15). After stirring the resulting solution overnight at room temperature, it was poured onto water (50 ml) and the resulting white precipitate was collected and air dried (yield 4.3 g; m.p. 160° C.).

후처리

  1. additionit was poured onto water (50 ml)
  2. customthe resulting white precipitate was collected
  3. customair dried (yield 4.3 g; m.p. 160° C.)

출처 및 근거

ORD 기록
ord-e6d0364450094fb992d558318d3066b3
출처 데이터셋
uspto-grants-1994_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US05304557

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