Ethanimidic acid, ethyl ester, hydrochloride (1:1) → N-((6-chloropyridin-3-yl)methyl)-N-methylethanimidamide hydrochloride
반응식
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][NH:9][CH3:10])=[CH:4][N:3]=1.Cl.[C:12](=[NH:17])(OCC)[CH3:13]>C(O)C>[ClH:1].[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([CH2:8][N:9]([CH3:10])[C:12](=[NH:17])[CH3:13])=[CH:4][N:3]=1참가 물질
4
실험 절차
To 40 ml of ethanol was added 5.1 g of N-(2-chloro-5-pyridylmethyl)-N-Methylamine and then 4 g of ethyl acetimidate hydrochloride at 0° C. After stirring for an hour, the reaction mixture was allowed to warm to room temperature and stirred over night. The solvent was then distilled off. The obtained white residue was washed with diethyl ether to afford 7.3 g of the title compound m.p. 192°-197° C.
후처리
- customat 0° C
- stirringstirred over night
- distillationThe solvent was then distilled off
- washThe obtained white residue was washed with diethyl ether
출처 및 근거
- ORD 기록
- ord-f2fdee4c7308435e9c9b9449b0ee2875
- 출처 데이터셋
- uspto-grants-1994_04
- 특허 번호
- US05304566
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