Ammonium Hydroxide → 2-Amino-pyrazino[2,3-b]pyridine

HRID 1464632노트

반응식

HRID 1464632 반응식
Cl[C:2]1[CH:11]=[N:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[N:3]=1.[OH-].[NH4+:13]>C(O)(C)C>[NH2:13][C:2]1[CH:11]=[N:10][C:5]2=[N:6][CH:7]=[CH:8][CH:9]=[C:4]2[N:3]=1

참가 물질

4

반응물 2

HCID 14923Ammonium HydroxideHCID 218561722-Chloropyrido[2,3-b]pyrazine

생성물 1

HCID 190871102-Amino-pyrazino[2,3-b]pyridine

시약·촉매·용매 1

HCID 3776Isopropanol용매

반응 조건

온도
115 °C

실험 절차

A mixture of 2-chloro-pyrazino[2,3-b]pyridine (3.35g), isopropanol (20 mL) and concentrated ammonium hydroxide (50 mL) was heated at 115° C. for 17 h in a sealed tube. The tube was cooled and the product was collected and recrystallized from ethanol to afford 2-amino-pyrazino[2,3-b]pyridine as a yellow solid.

후처리

  1. temperatureThe tube was cooled
  2. customthe product was collected
  3. customrecrystallized from ethanol

출처 및 근거

ORD 기록
ord-1bcb73e2563b4b7ebaf84d2454ea9024
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05306819

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