반응식
ClC(O[C:5]1[C:10]([CH3:11])=[CH:9][CH:8]=[CH:7][C:6]=1[CH3:12])=O.[FH:13]>>[CH3:12][C:6]1[CH:7]=[CH:8][CH:9]=[C:10]([CH3:11])[C:5]=1[F:13]참가 물질
3
반응 조건
- 온도
- 130 °C
실험 절차
2000 ml of anhydrous hydrogen fluoride were placed at 0° in a stainless steel laboratory autoclave and 500 g of 2,6-dimethylphenyl chloroformate were added dropwise. The autoclave was then sealed and heated at a maximum temperature of 130° C. for 3 hours. The pressure of the gases evolved was released at 26 bar. The autoclave was then cooled to room temperature and the excess hydrogen fluoride was distilled off. The remaining reaction mixture was poured onto ice and the organic phase was separated off and distilled under vacuum. 2,6-Dimethylfluorobenzene was obtained in a yield of 69%.
후처리
- additionwere added dropwise
- customThe autoclave was then sealed
- temperatureThe autoclave was then cooled to room temperature
- distillationthe excess hydrogen fluoride was distilled off
- customThe remaining reaction mixture
- additionwas poured onto ice
- customthe organic phase was separated off
- distillationdistilled under vacuum
출처 및 근거
- ORD 기록
- ord-a8a4e111f5ee4e41ad67b8ec08e03bda
- 출처 데이터셋
- uspto-grants-1994_04
- 특허 번호
- US05306849
연결된 노트
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