Hydrofluoric Acid → 2-Fluoro-m-xylene

HRID 1464718

반응식

HRID 1464718 반응식
[FH:1].Cl[C:3]([O:5][C:6]1[C:11]([CH3:12])=[CH:10][CH:9]=[CH:8][C:7]=1[CH3:13])=[O:4]>FC(F)(Cl)C(F)(Cl)Cl>[CH3:13][C:7]1[CH:8]=[CH:9][CH:10]=[C:11]([CH3:12])[C:6]=1[F:1].[F:1][C:3]([O:5][C:6]1[C:11]([CH3:12])=[CH:10][CH:9]=[CH:8][C:7]=1[CH3:13])=[O:4]

참가 물질

5

반응물 2

HCID 14917Hydrofluoric AcidHCID 2716182,6-Dimethylphenyl carbonochloridate

생성물 2

HCID 1230652-Fluoro-m-xyleneHCID 108448272,6-Dimethylphenylfluoroformate

시약·촉매·용매 1

HCID 6428Cfc 113용매

반응 조건

온도
160 °C

실험 절차

70 ml of hydrogen fluoride and 200 ml of 1,1,2-trifluoro-1,2,2-trichloroethane were placed at 0° C. in a stainless steel autoclave and 100 g of 2,6-dimethylphenyl chloroformate were added dropwise. The autoclave was sealed and heated at a maximum temperature of 160° C. for 5 hours, the pressure of the gases formed being released at 30 bar. The reaction mixture was worked up as described in Example 9. 2,6-Dimethylfluorobenzene was obtained in a yield of 30% and 2,6-dimethylphenyl fluoroformate in a yield of 40%. The latter can be added to a new batch for the preparation of 2,6-dimethylfluorobenzene (see Example 15).

후처리

  1. additionwere added dropwise
  2. customThe autoclave was sealed
  3. customthe pressure of the gases formed

출처 및 근거

ORD 기록
ord-641bd3e7226b4957978ba064149e165e
출처 데이터셋
uspto-grants-1994_04
특허 번호
US05306849

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