Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methyl chloroformate → N-cyclopropyl-2-[3-(3-thienyl)phenoxy]ethoxyacetamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methyl chloroformate | HCID 6586 | — |
| 반응물 | Triethylamine | HCID 8471 | — |
| 반응물 | Cyclopropylamine | HCID 69828 | — |
| 반응물 | 2-[3-(3-Thienyl)phenoxy]ethoxyacetic acid | HCID 19917129 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Diethyl Ether | HCID 3283 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 생성물 | N-cyclopropyl-2-[3-(3-thienyl)phenoxy]ethoxyacetamide | HCID 19917094 | — |
반응 단계
0.36 g of 2-[3-(3-thienyl)phenoxy]ethoxyacetic acid was dissolved in 7 ml of tetrahydrofuran, and under ice cooling, 110 μl of methyl chloroformate and 200 μl of triethylamine were added. After the mixture was stirred with cooling for 30 minutes, 178 μl of cyclopropylamine was added. The mixture was stirred at room temperature for 1 hour, and then ethyl ether and water were added. The organic layer separated was worked up in a customary manner to give 0.31 g of N-cyclopropyl-2-[3(3-thienyl)phenoxy]ethoxyacetamide as a pale yellow oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05306728 |
| 출처 데이터셋 | uspto-grants-1994_04 |
| ORD ID | ord-00b2379688df4f7bbced0f31c4d34416 |
| 출처 메모 | uspto-grants-1994_04 |