Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Propargyl alcohol → (E)-6,6-dimethyl-4-hepten-2-yn-1-ol
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Propargyl alcohol | HCID 7859 | — |
| 반응물 | Butylamine | HCID 8007 | — |
| 반응물 | Triphenylphosphine | HCID 11776 | — |
| 반응물 | (E)-1-iodo-3,3-dimethylbut-1-ene | HCID 11063689 | — |
| 촉매 | Palladium Chloride | HCID 24290 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | Water | HCID 962 | — |
| 용매 | Tetrahydrofuran | HCID 8028 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | (E)-6,6-dimethyl-4-hepten-2-yn-1-ol | HCID 19917005 | — |
반응 단계
0.63 g of (E)-1- iodo-3,3-dimethyl-1-butene [see J. Org. Chem., 43, 4424 (1978)] was dissolved in 10 ml of tetrahydrofuran, and 31 mg of triphenylphosphine, 29 mg of copper(I) iodide, 11 mg of palladium chloride, 1.5 ml of n-butylamine and 0.35 ml of propargyl alcohol were added. The mixture was stirred overnight at room temperature, and then water and ethyl acetate were added. The organic layer separated was worked up in a customary manner, and the product was purified by silica gel column chromatography [hexane/ethyl acetate=2/1] to give 0.27 g of the captioned compound as a pale brown oil.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US05306728 |
| 출처 데이터셋 | uspto-grants-1994_04 |
| ORD ID | ord-8bfc60aedb7d4839b58de804983eda20 |
| 출처 메모 | uspto-grants-1994_04 |