Hydrogen chloride-ethyl acetate → 4-Cyclobutoxy-6-(piperazin-1-yl)pyrimidine dihydrochloride

HRID 1464955노트

반응식

HRID 1464955 반응식
[CH:1]1([O:5][C:6]2[N:11]=[CH:10][N:9]=[C:8]([N:12]3[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14][CH2:13]3)[CH:7]=2)[CH2:4][CH2:3][CH2:2]1.[ClH:25].CCOC(C)=O>CCOC(C)=O>[ClH:25].[ClH:25].[CH:1]1([O:5][C:6]2[CH:7]=[C:8]([N:12]3[CH2:17][CH2:16][NH:15][CH2:14][CH2:13]3)[N:9]=[CH:10][N:11]=2)[CH2:4][CH2:3][CH2:2]1

참가 물질

4

반응물 2

HCID 21866389Hydrogen chloride-ethyl acetateHCID 66747845Tert-butyl 4-(6-cyclobutoxypyrimidin-4-yl)piperazine-1-carboxylate

생성물 1

HCID 667473944-Cyclobutoxy-6-(piperazin-1-yl)pyrimidine dihydrochloride

시약·촉매·용매 1

HCID 8857Ethyl Acetate용매

실험 절차

A mixture of tert-butyl 4-(6-cyclobutoxypyrimidin-4-yl)piperazine-1-carboxylate (687 mg, 2.06 mmol) and 4 M HCl-EtOAc (30 ml) were stirred at rt for 2 h. Then EtOAc was added, and the solvent was removed in vacuo. The residue was suspended in EtOAc, and the white precipitate was collected by filtration to give 525 mg (quant) of the title compound as a white solid. The compound was used for the next step without further purification.

후처리

  1. customthe solvent was removed in vacuo
  2. filtrationthe white precipitate was collected by filtration

출처 및 근거

ORD 기록
ord-a71444613f0f426181b450ba87fc8be5
출처 데이터셋
uspto-grants-2015_04
특허 번호
US08999974B2

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