4-Methyl-3-nitroaniline → tert-Butyl (4-methyl-3-nitrophenyl)carbamate

HRID 1465027노트

반응식

HRID 1465027 반응식
[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH2:6])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10].[C:12](=O)([OH:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15]>C1COCC1>[CH3:1][C:2]1[CH:8]=[CH:7][C:5]([NH:6][C:12](=[O:18])[O:13][C:14]([CH3:17])([CH3:16])[CH3:15])=[CH:4][C:3]=1[N+:9]([O-:11])=[O:10]

참가 물질

4

반응물 2

HCID 83904-Methyl-3-nitroanilineHCID 3015642Mono-tert-butyl carbonate

생성물 1

HCID 18954623tert-Butyl (4-methyl-3-nitrophenyl)carbamate

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매2회

반응 조건

온도
65 °C

실험 절차

4-Methyl-3-nitroaniline (5.0 g, 32.86 mmol) was dissolved in anhydrous THF (25 mL). t-Butyl bicarbonate (7.5 mL, 32.86 mmol) dissolved in anhydrous THF (25 mL) was added slowly to the reaction mixture, which was stirred at 65° C. for 18 hours. After the reaction was completed the remaining organic solvent was distilled under reduced pressure, and water was added thereto. The resulting yellow solid was filtered and dried to obtain the title compound without further purification.

후처리

  1. additionwas added slowly to the reaction mixture, which
  2. distillationwas distilled under reduced pressure, and water
  3. additionwas added
  4. filtrationThe resulting yellow solid was filtered
  5. customdried

출처 및 근거

ORD 기록
ord-d547698dd7ee4a56bca561fee49ee039
출처 데이터셋
uspto-grants-2015_04
특허 번호
US08999973B2

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