Thionyl Chloride → 4-Ethoxy-1-(4-fluorophenyl)pyrazole-3-carbonyl chloride

HRID 1465186노트

반응식

HRID 1465186 반응식
[CH2:1]([O:3][C:4]1[C:5]([C:16]([OH:18])=O)=[N:6][N:7]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:8]=1)[CH3:2].S(Cl)([Cl:21])=O>>[CH2:1]([O:3][C:4]1[C:5]([C:16]([Cl:21])=[O:18])=[N:6][N:7]([C:9]2[CH:14]=[CH:13][C:12]([F:15])=[CH:11][CH:10]=2)[CH:8]=1)[CH3:2]

참가 물질

3

반응물 2

HCID 24386Thionyl ChlorideHCID 336766774-ethoxy-1-(4-fluorophenyl)-1H-pyrazole-3-carboxylic acid

생성물 1

HCID 867081584-Ethoxy-1-(4-fluorophenyl)pyrazole-3-carbonyl chloride

실험 절차

D3 (43 mg, 0.17 mmol, 1.0 eq.) was heated in thionyl chloride (1 mL) for 4 h at 67° C. Solvent was removed in vacuo and the crude material was resolved in dry toluene and evaporated under reduced pressure again to yield D4. The crude material was used in the next step without further purification.

후처리

  1. customSolvent was removed in vacuo
  2. customevaporated under reduced pressure again

출처 및 근거

ORD 기록
ord-087e8d4a4f25427b845d58d767064a5c
출처 데이터셋
uspto-grants-2015_04
특허 번호
US08999982B2

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