1,5-Dimethyl-1H-Pyrazole-3-Carbonyl Chloride → N-[3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]phenyl]-1,5-dimethyl-pyrazole-3-carboxamide

HRID 1465200

반응식

HRID 1465200 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[O:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH2:23][CH2:24][CH2:25][N:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)=[C:17]([O:20][CH3:21])[CH:18]=2)[N:13]=[CH:12][CH:11]=1)[NH2:5].[CH3:32][N:33]1[C:37]([CH3:38])=[CH:36][C:35]([C:39](Cl)=[O:40])=[N:34]1>>[F:1][C:2]1[CH:3]=[C:4]([NH:5][C:39]([C:35]2[CH:36]=[C:37]([CH3:38])[N:33]([CH3:32])[N:34]=2)=[O:40])[CH:6]=[CH:7][C:8]=1[O:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH2:23][CH2:24][CH2:25][N:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)=[C:17]([O:20][CH3:21])[CH:18]=2)[N:13]=[CH:12][CH:11]=1

참가 물질

3

반응물 2

HCID 27763641,5-Dimethyl-1H-Pyrazole-3-Carbonyl ChlorideHCID 46928040HCID 46928040, 화합물

생성물 1

HCID 56846800N-[3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]phenyl]-1,5-dimethyl-pyrazole-3-carboxamide

실험 절차

Q5 was prepared from 3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]aniline and 1,5-dimethyl-1H-pyrazole-3-carbonyl chloride following the general procedure reported in Preparative Example 1 Step 3. MS (ES) C29H32FN5O5 requires: 549. Found: 550 (M+H)+.

출처 및 근거

ORD 기록
ord-0333246740124ccc95786828def1581a
출처 데이터셋
uspto-grants-2015_04
특허 번호
US08999982B2

연결된 노트

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