3-Fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)aniline → N-[3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]phenyl]-1-(4-fluorophenyl)-4-methoxy-pyrazole-3-carboxamide

HRID 1465201

반응식

HRID 1465201 반응식
[F:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][C:8]=1[O:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH2:23][CH2:24][CH2:25][N:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)=[C:17]([O:20][CH3:21])[CH:18]=2)[N:13]=[CH:12][CH:11]=1)[NH2:5].[F:32][C:33]1[CH:38]=[CH:37][C:36]([N:39]2[CH:43]=[C:42]([O:44][CH3:45])[C:41]([C:46](Cl)=[O:47])=[N:40]2)=[CH:35][CH:34]=1>>[F:1][C:2]1[CH:3]=[C:4]([NH:5][C:46]([C:41]2[C:42]([O:44][CH3:45])=[CH:43][N:39]([C:36]3[CH:37]=[CH:38][C:33]([F:32])=[CH:34][CH:35]=3)[N:40]=2)=[O:47])[CH:6]=[CH:7][C:8]=1[O:9][C:10]1[C:19]2[C:14](=[CH:15][C:16]([O:22][CH2:23][CH2:24][CH2:25][N:26]3[CH2:31][CH2:30][O:29][CH2:28][CH2:27]3)=[C:17]([O:20][CH3:21])[CH:18]=2)[N:13]=[CH:12][CH:11]=1

참가 물질

3

반응물 2

HCID 469280403-Fluoro-4-(6-methoxy-7-(3-morpholinopropoxy)quinolin-4-yloxy)anilineHCID 867081591-(4-Fluorophenyl)-4-methoxy-pyrazole-3-carbonyl chloride

생성물 1

HCID 56846802N-[3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]phenyl]-1-(4-fluorophenyl)-4-methoxy-pyrazole-3-carboxamide

실험 절차

Q7 was prepared from 3-fluoro-4-[[6-methoxy-7-(3-morpholinopropoxy)-4-quinolyl]oxy]aniline and E3 following the general procedure reported in Preparative Example 1 Step 3. 1H NMR (400 MHz, d6-DMSO, 300K) δ 2.01 (m, 2H), 2.51 (m, 6H), 3.61 (m, 4H), 3.86 (s, 3H), 3.94 (s, 3H), 4.20 (t, J=6.2 Hz, 2H), 6.46 (d, J=5.3 Hz, 1H), 7.43 (m, 4H), 7.53 (s, 1H), 7.72 (t, J=9.1 Hz, 1H), 8.01 (m, 3H), 8.47 (d, J=5.3 Hz, 1H), 8.49 (s, 1H), 10.19 (s, 1H). MS (ES) C34H33F2N6O6 requires: 645. Found: 646 (M+H)+.

출처 및 근거

ORD 기록
ord-0ab6477f32514ee79bdf58146f714a98
출처 데이터셋
uspto-grants-2015_04
특허 번호
US08999982B2

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