Potassium Hydroxide → 8-chloro-5-(2-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1,2-dimethyl-1H-pyrido[4,3-b]indole

HRID 1465327노트

반응식

HRID 1465327 반응식
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]2[NH:7][C:6]3[CH2:11][CH2:12][N:13]([CH3:16])[CH:14]([CH3:15])[C:5]=3[C:4]=2[CH:3]=1.[F:17][C:18]([F:28])([F:27])[C:19]1[CH:24]=[CH:23][C:22]([CH:25]=[CH2:26])=[CH:21][N:20]=1.[OH-].[K+]>CN1C(=O)CCC1>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]2[N:7]([CH2:26][CH2:25][C:22]3[CH:21]=[N:20][C:19]([C:18]([F:28])([F:17])[F:27])=[CH:24][CH:23]=3)[C:6]3[CH2:11][CH2:12][N:13]([CH3:16])[CH:14]([CH3:15])[C:5]=3[C:4]=2[CH:3]=1

참가 물질

5

반응물 3

HCID 14797Potassium HydroxideHCID 574168485-Ethenyl-2-(trifluoromethyl)pyridineHCID 687600668-chloro-2,3,4,5-tetrahydro-1,2-dimethyl-1H-pyrido[4,3-b]indole

생성물 1

HCID 578763118-chloro-5-(2-(6-(trifluoromethyl)pyridin-3-yl)ethyl)-2,3,4,5-tetrahydro-1,2-dimethyl-1H-pyrido[4,3-b]indole

시약·촉매·용매 1

HCID 13387N-methyl-2-pyrrolidone용매

실험 절차

The title compound is prepared from a mixture of, 8-chloro-2,3,4,5-tetrahydro-1,2-dimethyl-1H-pyrido[4,3-b]indole, 2-(trifluoromethyl)-5-vinylpyridine and KOH (5-7 equiv) in NMP at a temperature ranging between 25 deg C. to 100, deg C. The product obtained is isolated by preparative HPLC.

후처리

  1. customranging between 25 deg C
  2. customThe product obtained
  3. customis isolated by preparative HPLC

출처 및 근거

ORD 기록
ord-a589800aa90f4d39893dcd2ba79ca629
출처 데이터셋
uspto-grants-2015_04
특허 번호
US08999978B2

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