Thiophosgene → N-Benzo[1,3]dioxol-5-ylmethyl-thioformamide chloride

HRID 1465419

반응식

HRID 1465419 반응식
[CH2:1]([NH2:11])[C:2]1[CH:10]=[CH:9][C:8]2[O:7][CH2:6][O:5][C:4]=2[CH:3]=1.[C:12](Cl)([Cl:14])=[S:13]>ClCCl>[Cl-:14].[O:7]1[C:8]2[CH:9]=[CH:10][C:2]([CH2:1][NH:11][CH:12]=[S:13])=[CH:3][C:4]=2[O:5][CH2:6]1

참가 물질

4

반응물 2

HCID 10040ThiophosgeneHCID 75799Benzo-1,3-dioxole-5-methylamine

생성물 1

HCID 86601006N-Benzo[1,3]dioxol-5-ylmethyl-thioformamide chloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

To a stirred solution of piperonylamine (0.1 mL, 0.77 mmol) in dichloromethane (20 mL) was slowly added thiophosgene (0.06 mL, 0.83 mmol) under cooling with an ice bath. After the reaction mixture was stirred for four hours at room temperature, it was washed with water and brine, dried over anhydrous sodium sulfate, filtered, evaporated and dried under vacuum; and the product was used immediately for the next reaction.

후처리

  1. temperatureunder cooling with an ice bath
  2. washit was washed with water and brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. filtrationfiltered
  5. customevaporated
  6. customdried under vacuum
  7. customand the product was used immediately for the next reaction

출처 및 근거

ORD 기록
ord-fb90c08df403478591b15f74722d666b
출처 데이터셋
uspto-grants-2015_04
특허 번호
US08999988B2

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