Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Methanol → Amuvatinib
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Methanol | HCID 887 | — |
| 반응물 | Pyridine | HCID 1049 | — |
| 반응물 | 4-(Piperazin-1-yl)benzofuro[3,2-d]pyrimidine | HCID 2368542 | — |
| 반응물 | N-Benzo[1,3]dioxol-5-ylmethyl-thioformamide chloride | HCID 86601006 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | Amuvatinib | HCID 11282283 | — |
반응 단계
To a solution of 4-piperazinobenzofurano[3,2-d]pyrimidine (200 mg, 0.79 mmol) and pyridine (0.5 mL, 7.9 mmol) in dichloromethane (20 mL) was added a solution of product 1c in dichloromethane (20 mL) and this was stirred overnight. Methanol was added to quench excess thiophosgene, and the residue after removal of solvent was purified by silica gel column chromatography eluting with 5% methanol/dichloromethane and further recrystallized from dichloromethane/hexane to give 150 mg (37%).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US08999988B2 |
| 출처 데이터셋 | uspto-grants-2015_04 |
| ORD ID | ord-d0612be3ab1c4fc69aec090ac11f7680 |
| 출처 메모 | uspto-grants-2015_04 |