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Sodium Chloride → (R)-tert-butyl 5-(1-(1-(tert-butoxycarbonyl)piperidin-3-yl)-1H-1,2,3-triazol-4-yl)-3-(pyridin-4-yl)-1H-indazole-1-carboxylate

HRID 1465693
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HRID 1465693 반응식
[C:1]([C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[N:8]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[N:7]=[C:6]2[C:19]1[CH:24]=[CH:23][N:22]=[CH:21][CH:20]=1)#[CH:2].[N:25]([C@@H:28]1[CH2:33][CH2:32][CH2:31][N:30]([C:34]([O:36][C:37]([CH3:40])([CH3:39])[CH3:38])=[O:35])[CH2:29]1)=[N+:26]=[N-:27].[Na+].[Cl-]>CC(O)(C)C.O>[C:37]([O:36][C:34]([N:30]1[CH2:31][CH2:32][CH2:33][C@@H:28]([N:25]2[CH:2]=[C:1]([C:3]3[CH:4]=[C:5]4[C:9](=[CH:10][CH:11]=3)[N:8]([C:12]([O:14][C:15]([CH3:18])([CH3:17])[CH3:16])=[O:13])[N:7]=[C:6]4[C:19]3[CH:20]=[CH:21][N:22]=[CH:23][CH:24]=3)[N:27]=[N:26]2)[CH2:29]1)=[O:35])([CH3:40])([CH3:38])[CH3:39]
참가 물질실험 절차후처리출처 및 근거반응 노트

참가 물질

5

반응물 3

HCID 5234Sodium ChlorideHCID 86695573HCID 86695573, 화합물HCID 86695574tert-butyl 5-ethynyl-3-(pyridin-4-yl)-1H-indazole-1-carboxylate

생성물 1

HCID 86695575(R)-tert-butyl 5-(1-(1-(tert-butoxycarbonyl)piperidin-3-yl)-1H-1,2,3-triazol-4-yl)-3-(pyridin-4-yl)-1H-indazole-1-carboxylate수율 123.7%

시약·촉매·용매 1

HCID 71401949
2-Methylpropan-2-ol--water (1/1)
용매

실험 절차

Tert-butyl 5-ethynyl-3-(pyridin-4-yl)-1H-indazole-1-carboxylate (0.385 g, 1.2 mmol) and (R)-tert-butyl 3-azidopiperidine-1-carboxylate (0.273 g, 1.2 mmol) were suspended in t-BuOH:H2O (1:1, 15 mL:15 mL) and then CuSO4.5H2O (0.060 g, 0.24 mmol) and Na-Ascorbic acid (0.096 g, 0.48 mmol) were added sequentially. Reaction mixture was stirred vigorously at room temperature overnight. After the completion of reaction, added sat. NaCl (30 mL), extracted with EtOAc (3×50 mL), evaporated the organic solvent to give (R)-tert-butyl 5-(1-(1-(tert-butoxycarbonyl)piperidin-3-yl)-1H-1,2,3-triazol-4-yl)-3-(pyridin-4-yl)-1H-indazole-1-carboxylate (0.81 g) which was used for next step without purification.

후처리

  1. customReaction mixture
  2. customAfter the completion of reaction
  3. extractionextracted with EtOAc (3×50 mL)
  4. customevaporated the organic solvent

출처 및 근거

ORD 기록
ord-bab0027d93624c349e4d56bb495b80c1
출처 데이터셋
uspto-grants-2015_04
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US08999966B2

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