Trifluoroacetic acid → HCID 89525152, 화합물

반응식

[C:1]([C:3]1[CH:12]=[C:11]2[C:6]([CH:7]=[C:8]([N:13]3[CH2:18][CH2:17][N:16](C(OC(C)(C)C)=O)[CH2:15][C:14]3=[O:26])[CH:9]=[N:10]2)=[CH:5][CH:4]=1)#[N:2].C(O)(C(F)(F)F)=O>>[O:26]=[C:14]1[CH2:15][NH:16][CH2:17][CH2:18][N:13]1[C:8]1[CH:9]=[N:10][C:11]2[C:6]([CH:7]=1)=[CH:5][CH:4]=[C:3]([C:1]#[N:2])[CH:12]=2

참가 물질

반응물 2

HCID 6422Trifluoroacetic acid

HCID 131732664HCID 131732664, 화합물

생성물 1

HCID 89525152HCID 89525152, 화합물

실험 절차

tert-Butyl 4-(7-cyanoquinolin-3-yl)-3-oxopiperazine-1-carboxylate (0.030 g, 0.099 mmol) was treated with TFA (2 mL) and stirred for 20 minutes. Analysis of the reaction mixture by LC indicated that reaction had gone to completion. The solution was concentrated in vacuo and crude was azetroped with dichloroethane (3×8 mL) to furnish the title product. LC/MS (IE, m/z): [M+1]+=253.

후처리

customAnalysis of the reaction mixture by LC indicated that reaction
concentrationThe solution was concentrated in vacuo and crude

출처 및 근거

ORD 기록: ord-bdb65c0c4a6c45c3bfea573c18d43d16
출처 데이터셋: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08999991B2

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