Hydrochloric Acid → 1-Aminomethyl-6,7-dimethoxy-isoquinoline-4-carboxylic acid 4-methoxy-benzylamide hydrochloride

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As described in example 1, a solution of [6,7-dimethoxy-4-(4-methoxy-benzylcarbamoyl)-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester (84 mg) was treated with HCl in EtOAc to give 46 mg (69%) of 1-aminomethyl-6,7-dimethoxy-isoquinoline-4-carboxylic acid 4-methoxy-benzylamide hydrochloride: 1H NMR (DMSO-d6) δ 3.71 (s, 3H), 3.80 (s, 3H), 3.98 (s, 3H), 4.45 (d, 2H, J=6.03 Hz), 4.69-4.72 (m, 2H), 6.90 (d, 211, J=8.64 Hz), 7.32 (d, 2H, J=8.53 Hz), 7.44 (s, 1H), 7.61 (s, 1H), 8.46 (s, 1H), 8.59-8.62 (br s, 3H), 9.25 (t, 1H, J=6.53 Hz); MS: APCI (M−H) calc'd for C21H23N3O4 380.2; found 380.0.

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