3-Amino-N,N-dimethyl-4-nitroaniline → N4,N4-dimethylbenzene-1,2,4-triamine

HRID 1465802

반응식

HRID 1465802 반응식
[CH3:1][N:2]([CH3:13])[C:3]1[CH:4]=[CH:5][C:6]([N+:10]([O-])=O)=[C:7]([CH:9]=1)[NH2:8]>[Pd].C(OCC)(=O)C.CO>[NH2:8][C:7]1[CH:9]=[C:3]([N:2]([CH3:13])[CH3:1])[CH:4]=[CH:5][C:6]=1[NH2:10]

참가 물질

4

반응물 1

HCID 27334513-Amino-N,N-dimethyl-4-nitroaniline

생성물 1

HCID 417238N4,N4-dimethylbenzene-1,2,4-triamine

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 21584119Ethylacetate methanol용매

실험 절차

A solution of 5-dimethylamino-2-nitroaniline (1.94 g, 10.7 mmol) in 4:1 ethyl acetate/methanol (200 ml) was treated with 5% palladium on carbon (1.12 g) and stirred under an atmosphere of hydrogen at room temperature for 20.5 h. The suspension was quickly filtered through celite, the residue washed with methanol and the combined filtrate and washings concentrated to give the crude 2-amino-4-(dimethylamino)aniline as a dark brown oil, which was used without further purification in the next step.

후처리

  1. filtrationThe suspension was quickly filtered through celite
  2. washthe residue washed with methanol
  3. concentrationthe combined filtrate and washings concentrated

출처 및 근거

ORD 기록
ord-c3e59647387645ab94fce406eff33dbe
출처 데이터셋
uspto-grants-2015_04
특허 번호
US08999993B2

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