Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Hydrochloric Acid → 1-Aminomethyl-6,7-dimethoxy-isoquinoline-4-carboxylic acid benzyl-methyl-amide hydrochloride
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Hydrochloric Acid | HCID 313 | — |
| 반응물 | [4-(Benzyl-methyl-carbamoyl)-6,7-dimethoxy-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester | HCID 68613162 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-Aminomethyl-6,7-dimethoxy-isoquinoline-4-carboxylic acid benzyl-methyl-amide hydrochloride | HCID 46847166 | 79% |
반응 단계
As described in example 1, a solution of [4-(benzyl-methyl-carbamoyl)-6,7-dimethoxy-isoquinolin-1-ylmethyl]-carbamic acid tert-butyl ester (82 mg) was treated with HCl in EtOAc to give 56 mg (79%) of 1-aminomethyl-6,7-dimethoxy-isoquinoline-4-carboxylic acid benzyl-methyl-amide hydrochloride: 1H NMR (DMSO-d6) δ 2.68 (s, 2H), 3.67 (s, 2H), 3.91 (s, 1H), 3.97 (s, 3H), 4.33 (br s, 1H), 4.67-4.72 (m, 3H), 6.80 (s, 1H), 7.04-7.51 (m, 6H), 8.36 (d, 1H, J=4.26 Hz), 8.56-8.63 (m, 3H); MS: APCI (M+H) calc'd for C21H23N3O3 366.2; found 366.1.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732446B1 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-0461c1eb7f0f43598cc77b94c823513c |
| 출처 메모 | uspto-grants-2010_06 |