Trifluoroacetic acid → HCID 26192529, 화합물

HRID 1466005노트

반응식

HRID 1466005 반응식
[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][C@H:13]1[CH2:17][CH2:16][N:15](C(OC(C)(C)C)=O)[CH2:14]1.FC(F)(F)C(O)=O>>[CH:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][C:2]=1[O:11][CH2:12][C@H:13]1[CH2:17][CH2:16][NH:15][CH2:14]1

참가 물질

3

반응물 2

HCID 6422Trifluoroacetic acidHCID 67349749HCID 67349749, 화합물

생성물 1

HCID 26192529HCID 26192529, 화합물

실험 절차

The procedure is the same as for Example 2 (Stage 2.2) starting from 1.75 g (5.34 mmol) of tert-butyl (S)-3-(naphth-2-yloxymethyl)pyrrolidine-1-carboxylate and 5.00 ml (67.31 mmol) of trifluoroacetic acid. The product is obtained in the form of an oil after purification on a column of silica gel, elution being carried out with a dichloromethane/methanol/aqueous ammonia (90/9/1) mixture.

후처리

  1. customThe product is obtained in the form of an oil
  2. customafter purification
  3. washon a column of silica gel, elution

출처 및 근거

ORD 기록
ord-c3fe7ac69638490b831efef253fa47ff
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09000010B2

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