Methanol → Methyl 4-(1-aminocyclopropyl)benzoate
반응식
[NH2:1][C:2]1([C:5]2[CH:13]=[CH:12][C:8]([C:9]([OH:11])=[O:10])=[CH:7][CH:6]=2)[CH2:4][CH2:3]1.CO.[CH3:16][Si](C=[N+]=[N-])(C)C.CCCCCC>C1COCC1>[NH2:1][C:2]1([C:5]2[CH:13]=[CH:12][C:8]([C:9]([O:11][CH3:16])=[O:10])=[CH:7][CH:6]=2)[CH2:4][CH2:3]1참가 물질
6
실험 절차
4-(1-aminocyclopropyl)benzoic acid (1.75 g, 0.00988 mol) was stirred in THF (20 mL) and Methanol (10 mL) over ice/water bath. 2.00 M of trimethylsilyldiazomethane in hexane (9.9 mL, 0.020 mol) was added and the mixture was stirred at room temperature for 12 hours. The reaction mixture was concentrated down to viscous oil which solidified upon standing to give a crystalline solid. Crude material was dried on high vacuum line for 12 hours to give methyl 4-(1-aminocyclopropyl)benzoate (1.65 g, 87%) as pale brown solid.
후처리
- concentrationThe reaction mixture was concentrated down to viscous oil which
- customto give a crystalline solid
- customCrude material was dried on high vacuum line for 12 hours
출처 및 근거
- ORD 기록
- ord-7407d88d941c48b0880db251dbbbc6b4
- 출처 데이터셋
- uspto-grants-2015_04
- 특허 번호
- US09000024B2
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