Nitric Acid → N-(2-nitro-4-phenoxy-phenyl)acetamide

HRID 1466470노트

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HRID 1466470 반응식
[O:1]([C:8]1[CH:13]=[CH:12][C:11]([NH:14][C:15](=[O:17])[CH3:16])=[CH:10][CH:9]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[N+:18]([O-])([OH:20])=[O:19]>>[N+:18]([C:10]1[CH:9]=[C:8]([O:1][C:2]2[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=2)[CH:13]=[CH:12][C:11]=1[NH:14][C:15](=[O:17])[CH3:16])([O-:20])=[O:19]

참가 물질

3

반응물 2

HCID 944Nitric AcidHCID 80579N-(4-Phenoxyphenyl)acetamide

생성물 1

HCID 3828525N-(2-nitro-4-phenoxy-phenyl)acetamide

반응 조건

온도
-15 °C

실험 절차

N-(4-phenoxy-phenyl)-acetamide (1.00 g, 4.03 mmol) prepared in Step A was dissolved in fuming nitric acid (2 mL), and the mixture was stirred for 2 h at −15° C. After completion of the reaction, the reaction mixture was poured into 100 mL of ice water, which was then extracted with ethyl acetate. The extracted organic solution was dried over anhydrous magnesium sulfate, the solvent was removed under reduced pressure, and the residue was purified by column chromatography to give the title compound (0.67 g, 2.33 mmol).

후처리

  1. customAfter completion of the reaction
  2. extractionwas then extracted with ethyl acetate
  3. dry with materialThe extracted organic solution was dried over anhydrous magnesium sulfate
  4. customthe solvent was removed under reduced pressure
  5. customthe residue was purified by column chromatography

출처 및 근거

ORD 기록
ord-4e2860ca5f2b45109f1b46d7973998c3
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09000028B2

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