Thionyl Chloride → 3-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride

반응식

[CH3:1][N:2]1[CH:6]=[N:5][C:4]([CH2:7]O)=[N:3]1.O=S(Cl)[Cl:11]>>[ClH:11].[Cl:11][CH2:7][C:4]1[N:5]=[CH:6][N:2]([CH3:1])[N:3]=1

참가 물질

반응물 2

HCID 24386Thionyl Chloride

HCID 10351670(1-Methyl-1H-1,2,4-triazol-3-yl)methanol

생성물 1

HCID 225069273-(chloromethyl)-1-methyl-1H-1,2,4-triazole hydrochloride

실험 절차

(1-methyl-1H-1,2,4-triazol-3-yl)methanol (0.25 g, 2.2 mmol) was dissolved in 10 mL of SOCl2 and refluxed for 2 hours. The mixture was evaporated to dryness and coevaporated with toluene. The resulting white solid (0.2 g) was used in the next step without further purification.

후처리

temperaturerefluxed for 2 hours
customThe mixture was evaporated to dryness
customThe resulting white solid (0.2 g) was used in the next step without further purification

출처 및 근거

ORD 기록: ord-f8bbb8c4a75541d5942cb7421f31028e
출처 데이터셋: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US08999998B2

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