Ethanol → Ethyl 3-bromo-4-methoxybenzoate

HRID 1466813노트

반응식

HRID 1466813 반응식
[Br:1][C:2]1[CH:3]=[C:4]([CH:8]=[CH:9][C:10]=1[O:11][CH3:12])[C:5]([OH:7])=[O:6].OS(O)(=O)=O.[CH3:18][CH2:19]O>>[CH2:18]([O:6][C:5](=[O:7])[C:4]1[CH:8]=[CH:9][C:10]([O:11][CH3:12])=[C:2]([Br:1])[CH:3]=1)[CH3:19]

참가 물질

4

반응물 3

HCID 702EthanolHCID 1118Sulfuric AcidHCID 668363-Bromo-4-methoxybenzoic acid

생성물 1

HCID 23062539Ethyl 3-bromo-4-methoxybenzoate

실험 절차

3-Bromo-4-methoxy-benzoic acid (2.5 g, 11.6 mmol) was dissolved in EtOH (20 mL) and conc. H2SO4 (1 mL) was added. The reaction was heated to reflux overnight then submitted to standard aqueous workup. The residue was purified by silica gel chromatography (0-50% EtOAc in hexanes) to yield the title compound.

후처리

  1. temperatureThe reaction was heated
  2. temperatureto reflux overnight
  3. customThe residue was purified by silica gel chromatography (0-50% EtOAc in hexanes)

출처 및 근거

ORD 기록
ord-93cd1783997c4f829e87d3da859135cd
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09000025B2

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