Potassium Carbonate → HCID 66764966, 화합물

HRID 1466818노트

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HRID 1466818 반응식
[CH2:1]([O:3][C:4](=[O:25])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([S:13][C:14]2[C:22]3[C:17](=[CH:18][C:19]([Cl:23])=[CH:20][CH:21]=3)[NH:16][C:15]=2[CH3:24])[CH:6]=1)[CH3:2].C(=O)([O-])[O-].[K+].[K+].Br[C:33]1[CH:34]=[N:35][CH:36]=[CH:37][CH:38]=1>CN(C=O)C>[CH2:1]([O:3][C:4](=[O:25])[C:5]1[CH:10]=[CH:9][C:8]([O:11][CH3:12])=[C:7]([S:13][C:14]2[C:22]3[C:17](=[CH:18][C:19]([Cl:23])=[CH:20][CH:21]=3)[N:16]([C:33]3[CH:34]=[N:35][CH:36]=[CH:37][CH:38]=3)[C:15]=2[CH3:24])[CH:6]=1)[CH3:2]

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 122863-BromopyridineHCID 66765076HCID 66765076, 화합물

생성물 1

HCID 66764966HCID 66764966, 화합물

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

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온도
170 °C

실험 절차

3-(6-Chloro-2-methyl-1H-indol-3-ylsulfanyl)-4-methoxy-benzoic acid ethyl ester (0.175 g, 0.466 mmol) was combined with CuO (3.71 mg, 0.046 mmol), potassium carbonate (0.0805 g, 0.582 mmol) and 3-bromopyridine (0.229 mL, 2.33 mmol) in DMF (250 μL) and the reaction was heated to 170° C. overnight. After cooling the reaction was submitted to standard aqueous workup and the residue was purified by silica gel chromatography (0-100% (EtOAc:MeOH 98:2) in hexanes) to give the title compound.

후처리

  1. temperatureAfter cooling the reaction
  2. customthe residue was purified by silica gel chromatography (0-100% (EtOAc:MeOH 98:2) in hexanes)

출처 및 근거

ORD 기록
ord-69c888b7391149f8b691039ded8a867c
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09000025B2

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