3-Bromo-5-ethylpyridine → 3-[6-Chloro-1-(5-ethyl-pyridin-3-yl)-2-methyl-1H-indol-3-ylsulfanyl]-2-fluoro-benzoic acid ethyl ester

HRID 1466871노트

반응식

HRID 1466871 반응식
[CH2:1]([O:3][C:4](=[O:24])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[CH:16][C:17]([Cl:21])=[CH:18][CH:19]=3)[NH:14][C:13]=2[CH3:22])[C:6]=1[F:23])[CH3:2].Br[C:26]1[CH:27]=[N:28][CH:29]=[C:30]([CH2:32][CH3:33])[CH:31]=1>>[CH2:1]([O:3][C:4](=[O:24])[C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([S:11][C:12]2[C:20]3[C:15](=[CH:16][C:17]([Cl:21])=[CH:18][CH:19]=3)[N:14]([C:26]3[CH:27]=[N:28][CH:29]=[C:30]([CH2:32][CH3:33])[CH:31]=3)[C:13]=2[CH3:22])[C:6]=1[F:23])[CH3:2]

참가 물질

3

반응물 2

HCID 6428043-Bromo-5-ethylpyridineHCID 667653583-(6-Chloro-2-methyl-1H-indol-3-ylsulfanyl)-2-fluoro-benzoic acid ethyl ester

생성물 1

HCID 667653513-[6-Chloro-1-(5-ethyl-pyridin-3-yl)-2-methyl-1H-indol-3-ylsulfanyl]-2-fluoro-benzoic acid ethyl ester

실험 절차

Prepared according to the procedure described in Example 42, Step 4, using the following starting materials: 3-(6-chloro-2-methyl-1H-indol-3-ylsulfanyl)-2-fluoro-benzoic acid ethyl ester and 3-bromo-5-ethylpyridine.

후처리

  1. customPrepared

출처 및 근거

ORD 기록
ord-31961539b2f34098b150019aaa6ee3fc
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09000025B2

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