Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1466874생성일: 2026년 10월 26일
Sodium methanesulfinate → 3-(6-Methanesulfonyl-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid methyl ester
https://huagongshe.com/reaction/1466874
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Sodium methanesulfinate | HCID 2733271 | — |
| 반응물 | 3-(6-Bromo-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid methyl ester | HCID 66765362 | — |
| 촉매 | Copper(1+) iodide; Copper(I) iodide; Cuprous iodide; Cuprous iodide (CuI) | HCID 24350 | — |
| 용매 | N-methyl-2-pyrrolidone | HCID 13387 | — |
| 생성물 | 3-(6-Methanesulfonyl-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid methyl ester | HCID 66765038 | — |
반응 단계
3-(6-Bromo-2-methyl-1H-indol-3-ylsulfanyl)-benzoic acid methyl ester (0.113 g, 0.3 mmol), sodium methanesulfinate (0.138 g, 1.35 mmol), and copper(I) iodide (0.257 g, 1.35 mmol) were combined in NMP (3 mL) in a sealed reaction vessel and stirred at 140° C. for overnight. The resulting mixture was cooled to room temperature, and subjected to standard aqueous workup. The crude residue was purified by silica gel chromatography (10-100% EtOAc in hexanes) to afford the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| 특허 번호 | US09000025B2 |
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| 출처 데이터셋 | uspto-grants-2015_04 |
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| ORD ID | ord-900c4c1a9b034bad9f4f54da8762a7ef |
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| 출처 메모 | uspto-grants-2015_04 |
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