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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1468035생성일: 2026년 10월 26일

5-(Methylsulfonyl)-1H-indole → trans(+/-)-tert-Butyl-3-fluoro-4-((6-(5-(methylsulfonyl)-1H-indol-1-yl)pyridin-3-yl)oxy)piperidine-1-carboxylate

https://huagongshe.com/reaction/1468035

반응식

참여 물질

역할이름HCID투입량
반응물5-(Methylsulfonyl)-1H-indoleHCID 14973230—
반응물trans(+/-)-Tert-butyl-4-((6-chloropyridin-3-yl)oxy)-3-fluoropiperidine-1-carboxylateHCID 131732699—
생성물trans(+/-)-tert-Butyl-3-fluoro-4-((6-(5-(methylsulfonyl)-1H-indol-1-yl)pyridin-3-yl)oxy)piperidine-1-carboxylateHCID 67807149—

반응 단계

The title compound was prepared by following the similar procedure as described in Example-1 by using 5-(methylsulfonyl)-1H-indole (intermediate-21) and trans(±)-tert-butyl-4-((6-chloropyridin-3-yl)oxy)-3-fluoropiperidine-1-carboxylate (intermediate-63) (0.220 g, 37%).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US09000175B2
출처 데이터셋uspto-grants-2015_04
ORD IDord-8a75adf4647046bcac4ed8ea3ef395e2
출처 메모uspto-grants-2015_04