7-fluoro-1H-indole-5-carbonitrile → HCID 67809961, 화합물

반응식

Cl[C:2]1[N:7]=[CH:6][C:5]([O:8][CH:9]2[CH2:14][CH2:13][N:12]([C:15]([O:17][C:18]([CH3:21])([CH3:20])[CH3:19])=[O:16])[CH2:11][CH2:10]2)=[CH:4][CH:3]=1.[F:22][C:23]1[CH:24]=[C:25]([C:32]#[N:33])[CH:26]=[C:27]2[C:31]=1[NH:30][CH:29]=[CH:28]2>>[C:18]([O:17][C:15]([N:12]1[CH2:13][CH2:14][CH:9]([O:8][C:5]2[CH:6]=[N:7][C:2]([N:30]3[C:31]4[C:27](=[CH:26][C:25]([C:32]#[N:33])=[CH:24][C:23]=4[F:22])[CH:28]=[CH:29]3)=[CH:3][CH:4]=2)[CH2:10][CH2:11]1)=[O:16])([CH3:21])([CH3:20])[CH3:19]

참가 물질

반응물 2

HCID 38647287-fluoro-1H-indole-5-carbonitrile

HCID 86696180Tert-butyl 4-((6-chloropyridin-3-yl)oxy)piperidine-1-carboxylate

생성물 1

HCID 67809961HCID 67809961, 화합물

실험 절차

The title compound was prepared by following the similar procedure as described in Example-1 using tert-butyl 4-((6-chloropyridin-3-yl)oxy)piperidine-1-carboxylate (intermediate-6) and 7-fluoro-1H-indole-5-carbonitrile (0.085 g, 44%),

출처 및 근거

ORD 기록: ord-a8737175862c4d95ae0d32eae47f4072
출처 데이터셋: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09000175B2

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