3-[4-(4-Cyano-phenyl)-pyrazol-1-ylmethyl]-benzoic acid methyl ester → 3-[4-(4-Cyano-phenyl)-pyrazol-1-ylmethyl]-benzoic acid

HRID 1468177노트

반응식

HRID 1468177 반응식
C[O:2][C:3](=[O:24])[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([CH2:10][N:11]2[CH:15]=[C:14]([C:16]3[CH:21]=[CH:20][C:19]([C:22]#[N:23])=[CH:18][CH:17]=3)[CH:13]=[N:12]2)[CH:5]=1>CO.O>[C:22]([C:19]1[CH:18]=[CH:17][C:16]([C:14]2[CH:13]=[N:12][N:11]([CH2:10][C:6]3[CH:5]=[C:4]([CH:9]=[CH:8][CH:7]=3)[C:3]([OH:24])=[O:2])[CH:15]=2)=[CH:21][CH:20]=1)#[N:23]

참가 물질

3

반응물 1

HCID 675085333-[4-(4-Cyano-phenyl)-pyrazol-1-ylmethyl]-benzoic acid methyl ester

생성물 1

HCID 675082023-[4-(4-Cyano-phenyl)-pyrazol-1-ylmethyl]-benzoic acid수율 82.4%

시약·촉매·용매 1

HCID 22242641Methanol--water (1/1)용매

실험 절차

Add LiOH monohydrate (0.03 g, 0.8 mmol) to a suspension of 3-[4-(4-cyano-phenyl)-pyrazol-1-ylmethyl]-benzoic acid methyl ester (0.2 g, 0.6 mmol) in 5 mL of a 4:1 MeOH-water mixture and stir the reaction at room temperature overnight. Concentrate the reaction to remove most of the MeOH, dilute with additional H2O and neutralize by the addition of 1 N aqueous HCl. Isolate the resulting solid by filtration and dry to afford 0.15 g, 71% yield of 3-[4-(4-cyano-phenyl)-pyrazol-1-ylmethyl]-benzoic acid.

후처리

  1. customthe reaction at room temperature overnight
  2. concentrationConcentrate
  3. customthe reaction
  4. customto remove most of the MeOH
  5. additiondilute with additional H2O and neutralize by the addition of 1 N aqueous HCl
  6. customIsolate the resulting solid
  7. filtrationby filtration
  8. customdry

출처 및 근거

ORD 기록
ord-e61d724ed5f14b7782df7400fb053c02
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09000154B2

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