Sulfuric Acid → 4-Amino-2-chlorobenzenesulfonic acid

HRID 1468323

반응식

HRID 1468323 반응식
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[S:9](=O)(=[O:12])([OH:11])[OH:10]>>[NH2:5][C:4]1[CH:6]=[CH:7][C:8]([S:9]([OH:12])(=[O:11])=[O:10])=[C:2]([Cl:1])[CH:3]=1

참가 물질

3

반응물 2

HCID 1118Sulfuric AcidHCID 79323-Chloroaniline

생성물 1

HCID 158503594-Amino-2-chlorobenzenesulfonic acid

실험 절차

3-Chloroaniline, 0.4 ml, was slowly added to 4 ml of fuming sulfuric acid and stirred at room temperature overnight. While cooling to 0°, the reaction solution was poured onto water and the solid precipitated was separated by filtration. The solid filtered was dissolved in 2N sodium hydroxide aqueous solution and conc. hydrochloric acid was then added to the solution to make the liquid acidic. The solid precipitated was taken by filtration to give the crude product of 4-amino-2-chlorobenzenesulfonic acid.

후처리

  1. temperatureWhile cooling to 0°
  2. additionthe reaction solution was poured onto water
  3. customthe solid precipitated
  4. customwas separated by filtration
  5. filtrationThe solid filtered
  6. dissolutionwas dissolved in 2N sodium hydroxide aqueous solution
  7. additionconc. hydrochloric acid was then added to the solution
  8. customThe solid precipitated
  9. filtrationwas taken by filtration

출처 및 근거

ORD 기록
ord-1958819080d7405d9dd96db75c4f9aaf
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09000208B2

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