Ethanolamine → HCID 18706827, 화합물
반응식
Cl[C:2]1[C:7]([NH2:8])=[C:6]([Cl:9])[N:5]=[C:4]([NH2:10])[N:3]=1.[CH2:11]([CH2:13][NH2:14])[OH:12]>C(O)C>[NH2:10][C:4]1[N:3]=[C:2]([NH:14][CH2:13][CH2:11][OH:12])[C:7]([NH2:8])=[C:6]([Cl:9])[N:5]=1참가 물질
4
반응 조건
- 온도
- 105 °C
실험 절차
A mixture of 4,6-dichloropyrimidine-2,5-diamine (28 g, 156 mmol), ethanolamine (18 ml, 312 mmol) and ethanol (250 ml) were heated at 100-110° C. for 16 hours. The mixture was cooled and solvent was removed. To the residue methanol (100 ml) was added and stirred for 20 minutes. The solid was filtered off to obtain 2-[(2,5-diamino-6-chloro-pyrimidin-4-yl)amino]ethanol (22.0 g, 70%).
후처리
- temperatureThe mixture was cooled
- customsolvent was removed
- additionTo the residue methanol (100 ml) was added
- filtrationThe solid was filtered off
출처 및 근거
- ORD 기록
- ord-91f813d2a30a41c88ff9cc054e6507e6
- 출처 데이터셋
- uspto-grants-2015_04
- 특허 번호
- US09006177B2
반응 노트
불러오는 중…