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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 14687생성일: 2026년 10월 27일

Betahistine → (6,7-Dimethoxy-4-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-isoquinolin-1-ylmethyl)-carbamic acid tert-butyl ester

https://huagongshe.com/reaction/14687

반응식

참여 물질

역할이름HCID투입량
반응물BetahistineHCID 2366—
반응물[1-(Tert-butoxycarbonylamino-methyl)-6,7-dimethoxy-isoquinolin-4-yl]-acetic acidHCID 68613423—
생성물(6,7-Dimethoxy-4-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-isoquinolin-1-ylmethyl)-carbamic acid tert-butyl esterHCID 68614425—

반응 단계

As described in Example 1, 94 mg of [1-(tert-butoxycarbonylamino-methyl)-6,7-dimethoxy-isoquinolin-4-yl]-acetic acid was coupled with methyl-(2-pyridin-2-yl-ethyl)-amine to give 78 mg of (6,7-dimethoxy-4-{[methyl-(2-pyridin-2-yl-ethyl)-carbamoyl]-methyl}-isoquinolin-1-ylmethyl)-carbamic acid tert-butyl ester. MS: APCI (M+H) calc'd for C27H34N4O5+H 495.6; found 495.1.

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07732446B1
출처 데이터셋uspto-grants-2010_06
ORD IDord-a0fc57db664e4e9f91ce72fd47b39c29
출처 메모uspto-grants-2010_06