Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
(4-Methanesulfonylphenyl)methanol → 5-isopropyl-2-{4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidin-1-yl}pyrimidine
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | (4-Methanesulfonylphenyl)methanol | HCID 3801026 | — |
| 반응물 | {(1R,2R)-2-[1-(5-isopropylpyrimidin-2-yl)piperidin-4-yl]cyclopropyl}methanol | HCID 71128800 | — |
| 반응물 | 2-{4-[(1R,2R)-2-(iodomethyl)cyclopropyl]piperidin-1-yl}-5-isopropylpyrimidine | HCID 86717787 | — |
| 생성물 | 5-isopropyl-2-{4-[(1R,2R)-2-({[4-(methylsulfonyl)benzyl]oxy}methyl)cyclopropyl]piperidin-1-yl}pyrimidine | HCID 71128804 | — |
반응 단계
Using the procedure outlined in intermediate 8 (step B) the product from step C was reacted with 4-(methylsulfonyl)benzyl alcohol to yield the title compound. MS (ESI) m/z 444 [M+H]+. GPR119 Human EC50: 0.26 nM
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09006228B2 |
| 출처 데이터셋 | uspto-grants-2015_04 |
| ORD ID | ord-d0e9665830b04af08dd3e5b763fbca13 |
| 출처 메모 | uspto-grants-2015_04 |