Ethoxyacetyl chloride → 2-ethoxy-N-{4-[2-(1-hydroxycyclopropyl)ethylamino]quinolin-3-yl}acetamide hydrochloride

HRID 1469300노트

반응식

HRID 1469300 반응식
[CH2:1]([O:3][CH2:4][C:5]([Cl:7])=[O:6])[CH3:2].[NH2:8][C:9]1[CH:10]=[N:11][C:12]2[C:17]([C:18]=1[NH:19][CH2:20][CH2:21][C:22]1([OH:25])[CH2:24][CH2:23]1)=[CH:16][CH:15]=[CH:14][CH:13]=2>ClCCl>[ClH:7].[CH2:1]([O:3][CH2:4][C:5]([NH:8][C:9]1[CH:10]=[N:11][C:12]2[C:17]([C:18]=1[NH:19][CH2:20][CH2:21][C:22]1([OH:25])[CH2:23][CH2:24]1)=[CH:16][CH:15]=[CH:14][CH:13]=2)=[O:6])[CH3:2]

참가 물질

4

반응물 2

HCID 84189Ethoxyacetyl chlorideHCID 57457830HCID 57457830, 화합물

생성물 1

HCID 575154892-ethoxy-N-{4-[2-(1-hydroxycyclopropyl)ethylamino]quinolin-3-yl}acetamide hydrochloride

시약·촉매·용매 1

HCID 6344Dichloromethane용매

반응 조건

온도
2.5 °C

실험 절차

Ethoxyacetyl chloride (0.43 mL) was added to a cooled (0° C.) solution of 1-[2-(3-aminoquinolin-4-ylamino)ethyl]cyclopropanol (3.85 mmol) in dichloromethane (16 mL). The reaction mixture was stirred at 0-5° C. for 60 minutes and then concentrated under reduced pressure to provide crude 2-ethoxy-N-{4-[2-(1-hydroxycyclopropyl)ethylamino]quinolin-3-yl}acetamide hydrochloride.

후처리

  1. concentrationconcentrated under reduced pressure

출처 및 근거

ORD 기록
ord-0a12022d492b4d3b8443af0c37eb86a6
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09006264B2

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