Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,5-Dimethoxyphenylboronic acid → 3-[5-(2,5-Dimethoxy-phenyl)-pyridin-2-yloxy]-azetidine-1-carboxylic acid pyridazin-3-ylamide
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,5-Dimethoxyphenylboronic acid | HCID 2734342 | — |
| 반응물 | US10918640, Example 14 | HCID 66710496 | — |
| 생성물 | 3-[5-(2,5-Dimethoxy-phenyl)-pyridin-2-yloxy]-azetidine-1-carboxylic acid pyridazin-3-ylamide | HCID 44219055 | 83% |
반응 단계
This compound was prepared by the method outlined for example 5 step 6. Thus 3-(5-Iodo-pyridin-2-yloxy)-azetidine-1-carboxylic acid pyridazin-3-ylamide (100 mg, 0.25 mmol) was reacted with 2,5-Dimethoxybenzeneboronic acid (Cas. No 107099-99-0, 69 mg, 0.38 mmol) to afford title compound (84 mg, 83%) as an off-white powder. LCMS: (Method B) RT=1.19 min; m/z=408 [M+H]+.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US09006269B2 |
| 출처 데이터셋 | uspto-grants-2015_04 |
| ORD ID | ord-b872c864789c47d2a2b4d2e71fe78ed8 |
| 출처 메모 | uspto-grants-2015_04 |