Ammonium Chloride → 1-(3-(Trifluoromethyl)phenoxy)isoquinolin-5-amine

HRID 1469723노트

반응식

HRID 1469723 반응식
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[C:10]2[C:5]=1[CH:6]=[CH:7][N:8]=[C:9]2[O:14][C:15]1[CH:20]=[CH:19][CH:18]=[C:17]([C:21]([F:24])([F:23])[F:22])[CH:16]=1)([O-])=O.[NH4+].[Cl-]>CCO.O.[Fe]>[F:24][C:21]([F:22])([F:23])[C:17]1[CH:16]=[C:15]([CH:20]=[CH:19][CH:18]=1)[O:14][C:9]1[C:10]2[CH:11]=[CH:12][CH:13]=[C:4]([NH2:1])[C:5]=2[CH:6]=[CH:7][N:8]=1

참가 물질

6

반응물 2

HCID 25517Ammonium ChlorideHCID 866922295-Nitro-1-(3-(trifluoromethyl)phenoxy)isoquinoline

생성물 1

HCID 716780491-(3-(Trifluoromethyl)phenoxy)isoquinolin-5-amine수율 94.7%

시약·촉매·용매 3

HCID 23925Iron촉매HCID 702Ethanol용매HCID 962Water용매

실험 절차

The title compound was prepared following the procedure described in Step 3 of Intermediate-1 using 5-nitro-1-(3-(trifluoromethyl)phenoxy)isoquinoline (200 mg, 0.59 mmol), iron powder (267 mg, 4.7 mmol), and NH4Cl (312 mg, 5.9 mmol) in EtOH (4 mL) and water (1 mL) to afford 170 mg of the title product. 1H NMR (300 MHz, DMSO d6): δ 7.79 (d, J=5.7 Hz, 1H), 7.70-7.50 (m, 6H), 7.40 (t, J=7.8 Hz, 1H), 6.93 (d, J=7.2 Hz, 1H), 6.02 (br s, 2H).

후처리

  1. customThe title compound was prepared

출처 및 근거

ORD 기록
ord-b1e785c0e1e64a09aa7769bd05caecce
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09006257B2

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