8-Bromo-4-((4-methoxybenzyl)amino)quinoline-3-carboxylic acid → 8-bromo-N-(4-methoxybenzyl)quinolin-4-amine

HRID 1469740노트

반응식

HRID 1469740 반응식
[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][C:8](C(O)=O)=[C:7]2[NH:15][CH2:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=1>C1(OC2C=CC=CC=2)C=CC=CC=1>[Br:1][C:2]1[CH:3]=[CH:4][CH:5]=[C:6]2[C:11]=1[N:10]=[CH:9][CH:8]=[C:7]2[NH:15][CH2:16][C:17]1[CH:22]=[CH:21][C:20]([O:23][CH3:24])=[CH:19][CH:18]=1

참가 물질

3

반응물 1

HCID 866922348-Bromo-4-((4-methoxybenzyl)amino)quinoline-3-carboxylic acid

생성물 1

HCID 866922358-bromo-N-(4-methoxybenzyl)quinolin-4-amine수율 101.6%

시약·촉매·용매 1

HCID 7583Diphenyl Ether용매

실험 절차

A solution of 8-bromo-4-((4-methoxybenzyl)amino)quinoline-3-carboxylic acid (1.0 g, 2.58 mmol) in diphenyl ether (5 mL) was heated at 240° C. for 30 min. Then petroleum ether was added to the reaction mixture at rt and the precipitated solid was filtered and dried to afford 900 mg of the title product. 1H NMR (300 MHz, DMSO d6): δ 8.38 (d, J=5.4 Hz, 1H), 8.34-8.31 (d, J=9.0 Hz, 1H), 8.06 (t, 1H), 8.02-7.99 (d, J=7.5 Hz, 1H), 7.37-7.29 (m, 3H), 6.90-6.87 (d, J=8.4 Hz, 2H), 6.44 (d, J=5.1 Hz, 1H), 4.49 (d, J=6.0 Hz, 2H), 3.71 (s, 3H).

후처리

  1. filtrationthe precipitated solid was filtered
  2. customdried

출처 및 근거

ORD 기록
ord-181b20f5156041019c5acbad86612801
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09006257B2

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