Acetic Acid → 5-bromo-7-methylquinazolin-4(3H)-one
반응식
[CH3:1][C:2]1[CH:11]=[C:10]2[C:5]([C:6](=[O:12])[NH:7][CH:8]=[N:9]2)=[CH:4][CH:3]=1.CO.CC(O)=O.[Br:19]Br>>[Br:19][C:4]1[CH:3]=[C:2]([CH3:1])[CH:11]=[C:10]2[C:5]=1[C:6](=[O:12])[NH:7][CH:8]=[N:9]2참가 물질
5
실험 절차
To a solution of 7-methylquinazolin-4(3H)-one (900 mg, 5.63 mmol) in MeOH (180 mg, 5.63 mmol) and AcOH (5.07 g, 84.45 mmol) was added bromine (300 μL, 5.63 mmol) and the reaction mixture was stirred at rt for 4 h. Then the reaction mixture was quenched with an aq. solution of sodium thiosulphate. The precipitate obtained was filtered and dried to afford 900 mg of the title product. 1H NMR (300 MHz, DMSO-d6): δ 12.24 (br s, 1H), 8.18 (s, 1H), 8.08 (s, 1H), 7.66 (s, 1H), 2.48 (s, 3H).
후처리
- customThen the reaction mixture was quenched with an aq. solution of sodium thiosulphate
- customThe precipitate obtained
- filtrationwas filtered
- customdried
출처 및 근거
- ORD 기록
- ord-bb17728b65a34f65a65c3a1a9155ae1a
- 출처 데이터셋
- uspto-grants-2015_04
- 특허 번호
- US09006257B2
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