2-Bromoethyl methyl ether → 5-(4,4-Difluorocyclohexyl)-3-(2-methoxyethyl)thiazol-2(3h)-imine hydrobromide

반응식

[F:1][C:2]1([F:14])[CH2:7][CH2:6][CH:5]([C:8]2[S:12][CH:11]([NH2:13])[NH:10][CH:9]=2)[CH2:4][CH2:3]1.[CH3:15][O:16][CH2:17][CH2:18][Br:19]>>[BrH:19].[F:14][C:2]1([F:1])[CH2:7][CH2:6][CH:5]([C:8]2[S:12][C:11](=[NH:13])[N:10]([CH2:18][CH2:17][O:16][CH3:15])[CH:9]=2)[CH2:4][CH2:3]1

참가 물질

반응물 2

HCID 809722-Bromoethyl methyl ether

HCID 66859799HCID 66859799, 화합물

생성물 1

HCID 668595395-(4,4-Difluorocyclohexyl)-3-(2-methoxyethyl)thiazol-2(3h)-imine hydrobromide

실험 절차

A mixture of Example 184E and commercially available 2-bromoethyl methyl ether (Aldrich) was processed using the method described in Example 46A to afford the title compound. MS (ESI+) m/z 277 (M+H)+.

출처 및 근거

ORD 기록: ord-2d26b41cd3404ce6b7488d92299266c9
출처 데이터셋: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09006275B2

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