Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2,4-Dichloropyrimidine → 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2,4-Dichloropyrimidine | HCID 77531 | — |
| 반응물 | 3-Formylphenylboronic acid | HCID 2734356 | — |
| 생성물 | 3-(2-Chloro-pyrimidin-4-yl)-benzaldehyde | HCID 24901965 | 60% |
반응 단계
2,4 dichloropyrimidine and 3-formyl phenyl boronic acid were coupled following procedure A. The yield was 60%. LC-MS showed the product was >95% pure and had the expected M+H+ of 219. 1H NMR (Varian 300 MHz, CDCl3, shifts relative to the solvent peak at 7.24 ppm) 610.1 (s, 1H) 8.7 (d, 1H) 8.6 (m, 1H) 8.4 (m, 1H) 8.1 (m, 1H) 7.7 (m, 2H).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07732444B2 |
| 출처 데이터셋 | uspto-grants-2010_06 |
| ORD ID | ord-e0e0050b65ba4b42a63f0cab5037d450 |
| 출처 메모 | uspto-grants-2010_06 |