Piperidine → (1-Chloro-5-methylisoquinolin-4-yl)(piperidin-1-yl)methanone

HRID 1470464노트

반응식

[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([OH:15])=O)=[CH:4][N:3]=1.[NH:16]1[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]1>>[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([N:16]2[CH2:21][CH2:20][CH2:19][CH2:18][CH2:17]2)=[O:15])=[CH:4][N:3]=1

참가 물질

반응물 2

HCID 8082Piperidine

HCID 84687221HCID 84687221, 화합물

생성물 1

HCID 86689580(1-Chloro-5-methylisoquinolin-4-yl)(piperidin-1-yl)methanone

실험 절차

The title compound was prepared by using 1-chloro-5-methylisoquinolin-4-carboxylic acid (Intermediate-10) and piperidine by following the similar procedure as described for intermediate-11a.

출처 및 근거

ORD 기록: ord-800a51f1ea744a158844233cb4441def
출처 데이터셋: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09006442B2

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