2,6-Dimethylpiperazine → (1-Chloro-5-methylisoquinolin-4-yl)(3,5-dimethylpiperazin-1-yl)methanone

반응식

[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([OH:15])=O)=[CH:4][N:3]=1.[CH3:16][CH:17]1[CH2:22][NH:21][CH2:20][CH:19]([CH3:23])[NH:18]1>>[Cl:1][C:2]1[C:11]2[C:6](=[C:7]([CH3:12])[CH:8]=[CH:9][CH:10]=2)[C:5]([C:13]([N:21]2[CH2:20][CH:19]([CH3:23])[NH:18][CH:17]([CH3:16])[CH2:22]2)=[O:15])=[CH:4][N:3]=1

참가 물질

반응물 2

HCID 660562,6-Dimethylpiperazine

HCID 84687221HCID 84687221, 화합물

생성물 1

HCID 86689584(1-Chloro-5-methylisoquinolin-4-yl)(3,5-dimethylpiperazin-1-yl)methanone

실험 절차

This compound was prepared by using 1-chloro-5-methylisoquinolin-4-carboxylic acid (Intermediate-10) and 2,6-dimethylpiperazine by following the similar procedure as described for intermediate-11a.

후처리

customThis compound was prepared

출처 및 근거

ORD 기록: ord-0c12ec6195744b229a28b670eeea3a63
출처 데이터셋: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09006442B2

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