Nitric Acid → 5-Fluoro-7-nitroindole-2,3-dione
반응식
[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[O:12].[N+:13]([O-])([OH:15])=[O:14]>OS(O)(=O)=O>[F:1][C:2]1[CH:3]=[C:4]2[C:8](=[C:9]([N+:13]([O-:15])=[O:14])[CH:10]=1)[NH:7][C:6](=[O:11])[C:5]2=[O:12]참가 물질
4
실험 절차
To a solution of 5-fluoro-1H-indole-2,3-dione (2.5 g, 15.0 mmol) in conc. H2SO4 (9 mL) was added very slowly fuming nitric acid (1.5 mL) at −5 to 0° C. The reaction mixture was stirred at the same temperature for one hour. After completion of the reaction, the reaction mixture was poured onto crushed ice and the resulting precipitate was filtered, washed with water (2-3 times) and dried under vacuum to obtain the title compound as yellow solid (3 g, 94.30%) which was used for the next step directly.
후처리
- customAfter completion of the reaction
- additionthe reaction mixture was poured
- customonto crushed ice
- filtrationthe resulting precipitate was filtered
- washwashed with water (2-3 times)
- customdried under vacuum
출처 및 근거
- ORD 기록
- ord-c62581fc360a4378a3109ff931816cfe
- 출처 데이터셋
- uspto-grants-2015_04
- 특허 번호
- US09006454B2
반응 노트
불러오는 중…