Sulfuric Acid → 7-Iodoisatin

HRID 1470637노트

반응식

HRID 1470637 반응식
ON=[CH:3][C:4]([NH:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][C:8]=1[I:13])=[O:5].[OH:14]S(O)(=O)=O>>[I:13][C:8]1[CH:9]=[CH:10][CH:11]=[C:12]2[C:7]=1[NH:6][C:4](=[O:5])[C:3]2=[O:14]

참가 물질

3

반응물 2

HCID 1118Sulfuric AcidHCID 63998232-(Hydroxyimino)-N-(2-iodophenyl)acetamide

생성물 1

HCID 40437057-Iodoisatin수율 87%

반응 조건

온도
85 °C

실험 절차

2-(hydroxyimino)-N-(2-iodophenyl)acetamide (3.2 g, 0.011 mmol) was added to conc. H2SO4 (15 mL) in small portions at 60° C. The reaction mixture was further heated at 85° C. for 5 h. After the reaction completion, the reaction mixture was cooled to room temperature and poured into crushed ice. A brown color solid product precipitated. It was then filtered and washed with chilled water several times, then dried in a vacuum oven to get 2.9 g of the required product as a red coloured solid (87%).

후처리

  1. temperatureAfter the reaction completion, the reaction mixture was cooled to room temperature
  2. additionpoured
  3. custominto crushed ice
  4. customA brown color solid product precipitated
  5. filtrationIt was then filtered
  6. washwashed with chilled water several times
  7. customdried in a vacuum oven

출처 및 근거

ORD 기록
ord-1b14c10ffc9f42068fb6b542d51a8c66
출처 데이터셋
uspto-grants-2015_04
특허 번호
US09006454B2

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