HCID 68733852, 화합물 → HCID 68735663, 화합물

반응식

[Si]([O:8][C@@H:9]1[CH2:17][C@@H:12]2[O:13][C:14](=[O:16])[CH2:15][C@@H:11]2[C@H:10]1[CH:18]=[CH:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25])(C(C)(C)C)(C)C>CO.[Pd]>[OH:8][C@@H:9]1[CH2:17][C@@H:12]2[O:13][C:14](=[O:16])[CH2:15][C@@H:11]2[C@H:10]1[CH2:18][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][CH2:24][CH3:25]

참가 물질

실험 절차

A mixture of 5-2 (595 mg, 1.62 mmol) and 5% Pd/C (556 mg, 0.17 mmol) in methanol (80 mL) was stirred under 1 atm H2 pressure (balloon) overnight. The mixture was then filtered through Celite and the filtrate evaporated. Purification of the residue by flash chromatography on silica gel (Isco Combiflash unit) gave the title compound (396 mg, 96%).

후처리

filtrationThe mixture was then filtered through Celite
customthe filtrate evaporated
customPurification of the residue by flash chromatography on silica gel (Isco Combiflash unit)

출처 및 근거

ORD 기록: ord-5fe96b28a459454dac2c226570ba23f7
출처 데이터셋: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09006464B2

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참가 물질

반응물 1

HCID 68733852HCID 68733852, 화합물

생성물 1

HCID 68735663HCID 68735663, 화합물수율 96.1%

시약·촉매·용매 2

HCID 23938Palladium촉매

HCID 887Methanol용매

실험 절차

후처리

filtrationThe mixture was then filtered through Celite
customthe filtrate evaporated
customPurification of the residue by flash chromatography on silica gel (Isco Combiflash unit)

출처 및 근거

ORD 기록: ord-5fe96b28a459454dac2c226570ba23f7
출처 데이터셋: uspto-grants-2015_04
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US09006464B2

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불러오는 중…