Methylamine → N-methyl-2-chlorothiazole-4-carboxamide
반응식
[Cl:1][C:2]1[S:3][CH:4]=[C:5]([C:7](Cl)=[O:8])[N:6]=1.[CH2:10]([N:12](CC)CC)C.CN>ClCCl.C1COCC1>[CH3:10][NH:12][C:7]([C:5]1[N:6]=[C:2]([Cl:1])[S:3][CH:4]=1)=[O:8]참가 물질
6
실험 절차
To 445 mg (2.44 mmol) 2-chloro-thiazole-4-carbonyl chloride in 8.0 mL dichloromethane is added a mixture of 0.38 mL (2.69 mmol) triethylamine and 1.35 mL (2.69 mmol) 2 molars solution of methylamine in THF. The mixture is stirred over night, concentrated and the residue is treated with water and NaHCO3 solution. After extraction with ethylacetate the organic phases are combined, dried (Na2SO4) and concentrated to yield the desired product
후처리
- concentrationconcentrated
- additionthe residue is treated with water and NaHCO3 solution
- extractionAfter extraction with ethylacetate the organic phases
- dry with materialdried (Na2SO4)
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-c3330bf45f2045e28397d1296808a72a
- 출처 데이터셋
- uspto-grants-2015_04
- 특허 번호
- US09006450B2
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