[CH3:1][N+:2]1([CH3:26])[C@@H:7]2[C@@H:8]3[O:10][C@@H:9]3[C@H:3]1[CH2:4][C@@H:5]([O:11][C:12]([C:14]([OH:25])([C:20]1[S:24][CH:23]=[CH:22][CH:21]=1)[C:15]1[S:19][CH:18]=[CH:17][CH:16]=1)=[O:13])[CH2:6]2.O.[Br-:28].[CH2:29]([OH:51])[C@H:30]1[O:35][C@H:34]([O:36][C@H:37]2[O:42][C@H:41]([CH2:43][OH:44])[C@@H:40]([OH:45])[C@H:39]([OH:46])[C@H:38]2[OH:47])[C@H:33]([OH:48])[C@@H:32]([OH:49])[C@@H:31]1[OH:50].[NH2:52][C@H:53]([C:58]([OH:60])=[O:59])[CH2:54][CH:55]([CH3:57])[CH3:56].CO>O>[CH3:1][N+:2]1([CH3:26])[C@@H:3]2[C@@H:9]3[O:10][C@@H:8]3[C@H:7]1[CH2:6][C@@H:5]([O:11][C:12]([C:14]([OH:25])([C:15]1[S:19][CH:18]=[CH:17][CH:16]=1)[C:20]1[S:24][CH:23]=[CH:22][CH:21]=1)=[O:13])[CH2:4]2.[OH2:35].[Br-:28].[CH2:43]([OH:44])[C@H:41]1[O:42][C@H:37]([O:36][C@H:34]2[O:35][C@H:30]([CH2:29][OH:51])[C@@H:31]([OH:50])[C@H:32]([OH:49])[C@H:33]2[OH:48])[C@H:38]([OH:47])[C@@H:39]([OH:46])[C@@H:40]1[OH:45].[NH2:52][C@H:53]([C:58]([OH:60])=[O:59])[CH2:54][CH:55]([CH3:57])[CH3:56]Tiotropium bromide (1.4 g), trehalose dehydrate (0.3 g) and L-leucine (0.3 g) were dissolved into methanol (60 ml). The solution was shaken. Water (60 ml) was added and shaken until dissolution occurred. The resultant solution was spray dried according to the parameters outlined below.
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